Strength of evidence: C+
The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin
Authors: Chorin E et al
Journal: Pre-prints (MedRXIV)
Objectives: Study the effect of Hydroxychloroquine/Azithromycin combination on QT
Strength of evidence: C+ (Pre-prints, low detail on methods, heterogeneous population, short ECG follow up)
Methods/publication type: Retrospective Cohort study 84 patients in New York
Highlights :
QT corrected been extended under treatment from 435 ± 24 ms 436 ± 32 ms (p <0.001) after 3.6 days of treatments (average)
The QTc was increased by 30 ms on average in the treated patients and for 11% of them, the QTc exceeded 500 ms without torsade de pointe
The development of acute renal failure could be a predictor of a significant increase in QTc
Baseline QTc is not a predictor for a later increase in QTc
Patients treated with a combination of hydroxychloroquine and azithromycin may be at risk of fatal cardiac arrhythmia
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