Outcomes in severely ill patients, a multicentric retrospective cohort study (50 US states)

Quality of evidence: C

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Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19)

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Authors: CDC COVID-19 Response Team

Journal: The Morbidity and Mortality Weekly Report (MMWR) from the CDC

Objectives: Assess the occurrence of hospitalizations, intensive care, and death among US COVID-19 patients

Strength of evidence: Low (Multicentric but retrospective preliminary descriptive study, many cases have missing data points)

Methods/publication type:

• A multicentric retrospective cohort study (descriptive)

• 49+ states in the United States

• Between February 12 and March 16

Highlights :

• 12% of patients hospitalized

• Over 121 patients in intensive care: 7% >85 y / 46% 65-84 y / 36% 45-64 y / 12% 20-44 y

• Fatality rate was highest in persons aged ≥85, ranging from 10% to 27%

• It was between 3% to 11% among persons aged 65–84 years

• It was between 1% to 3% among persons aged 55-64 years

• It was <1% among persons aged 20–54 years

• No fatalities or admission in intensive care among persons aged ≤19 years

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