Quality of evidence: B-
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Authors: Zhou F et al
Journal: The Lancet
Objectives: Identify the characteristics of patients with COVID-19 and the risk factors for death
Strength of evidence: Moderate (well-designed cohort study, however retrospective, a limited number of deceased patients, heterogeneous population)
Methods/publication type: Retrospective multicenter cohort study on patients affected by COVID-19 in Wuhan
Highlights :
Out of 191 hospitalized patients, 137 (72%) were cured and 54 (28%) died
91 (48%) had comorbidities, mainly hypertension (30%), diabetes (19%) and coronary artery disease (8%)
Risk factors for mortality: age over 70, comorbidities (hypertension, diabetes, coronary artery disease) and if resuscitation was performed
The Sequential Organ Failure Assessment (SOFA) score was useful to predict the risk of death
Increased signs of severity: FR> 24, SOFA score> 6, GB> 10G, lymphocytes <0.02G, creat> 133
Lactate> 245, tropo> 28, D-Dimer> 1 and they increase with time in non-survivors
The median duration of infection is 20 days (IQR 17 · 0–24 · 0)
Chronology of appearance of symptoms is not different between the level of prognosis: the first day = cough + fever, day 6 = dyspnea, then disappearance of cough + fever but need intensive care between D12 and D18
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