Quality of evidence: C
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)
Authors: Guo T et al.
Journal: JAMA Cardiology
Objectives: Explore the link between cardiovascular disease/heart injury with fatality
Strength of evidence: Low (retrospective, monocentric, low n of fatalities, other disorders might be confounders)
Methods/publication type:
Retrospective monocentric study
Wuhan (23 January to 23 February)
187 patients, 43 deceased
Average age = 58.5 yo
Highlights :
35.3% of patients with cardiovascular risk factors (hypertension, coronary disease, cardiomyopathy) and 27,8% with heart injury (high troponins)
Higher troponin in patients with cv background (54.5% vs 13.2%)
Patients with higher troponin in patients often used ACE inhibitors or angiotensin receptor blockers
Higher risk of arrhythmia, corticoid treatment or mechanical ventilation with high troponin
Death rate higher with high troponin and cv background (69,44%) vs 37.5% in patients with only high troponin, 13.3% in patients with only cv background and 7.62% in patients without cv background or high troponins: heart injury most associated with a death rate
Heart injury possibly linked to cytokine storm, anti-inflammatory treatments might be useful
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